Welcome to PathFX

PathFX is designed to look at the pathways-level effects (pathway "FX") of a drug intervention. Under the hood, PathFX is an interaction-network tool that searches for the most relevant protein-protein interactions around a drug's target(s), and then analyzes for which phenotypes the network is enriched relative to the entire interaction network. The algorithm and the web application provide tabular results of associated phenotypes, and a summary figure and table of phenotype clusters based on semantic similarity between phenotypes.

High-level workflow for PathFX

After logging in or registering:

1. Submit your query by clicking on the Run PathFX button
2. PathFX will analyze for phenotypes where the network is relatively enriched, compared to the entire interaction network
3. When finished, PathFX will send e-mail notification and store the results
4. Use the e-mailed link or visit the PathFX Jobs page to visualize and/or download your results.

This PathFX web application has been tested to work using the Google Chrome browser.

Log in to Start Using PathFX New users register here

To try our live examples, please register

You can download a pre-computed example for Metformin (10kB)