PathFX is designed to look at the pathways-level effects (pathway "FX") of a drug intervention. Under the hood, PathFX is an interaction-network tool that searches for the most relevant protein-protein interactions around a drug's target(s), and then analyzes for which phenotypes the network is enriched relative to the entire interaction network. The algorithm and the web application provide tabular results of associated phenotypes, and a summary figure and table of phenotype clusters based on semantic similarity between phenotypes.
This PathFX web application has been tested to work using the Google Chrome browser.Log in to Start Using PathFX New users register here
To try our live examples, please register
You can download a pre-computed example for Metformin (10kB)